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Elevation of a novel angiogenic factor, leucine-rich-α2-glycoprotein (LRG1), is associated with arterial stiffness, endothelial

Endocrinology
Author
Pek, S. L. et al.
Used Parameters : PBF

Publication Year : 2015

Country : Singapore

Journal : Journal of Clinical Endocrinology & Metabolism

Context: Increased arterial stiffness and endothelial dysfunction are associated with peripheral arterial disease (PAD). Leucine-rich-α2-glycoprotein (LRG1) is a proangiogenic factor involved in regulation of the TGFβ signaling pathway. Objective: This study in patients with type 2 diabetes mellitus explored the associations of plasma LRG1 with arterial stiffness, endothelial function, and PAD. Design: Based on the ankle brachial index (ABI), patients were classified as having PAD (ABI≤ 0.9) or as being borderline abnormal (ABI …
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